Antimicrobial Resistance- Part 4

From the chalkboard lecture:

1. As of today, how many cases of swine flu have been reported in Mexico? How many deaths?

2. As of today, how many cases of swine flu have been reported in the USA? How many deaths?

3. What two drugs can be used to treat those infected with swine flu? (both brand name and generic name of each)

4. What has NYC done to try to prepare for a swine flu pandemic?

PROTECT YOURSELF
http://www.youtube.com/watch?v=ZlDqcmY_EV8&eurl=http%3A%2F%2Fwww.pandemicflu.gov%2F&feature=player_embedded

KNOW THE SYMPTOMS
http://www.youtube.com/watch?v=0wK1127fHQ4&feature=channel

---FUNGI---

What gene is upregulated in yeasts which are resistant to fluconazole? In addition to upregulation of lanosterol 14 alpha-demethylase (ERG11), how else can the yeast cells decrease the effects of a drug? Why do we worry about fluconazole-resistance anyway?

What is a fungistatic compound? Can you name one? What is a fungicidal compound? Can you name one? What kind of drug is fluconazole? Why do fungistatic drugs eventually stop working in immunocompromised people? Are immunocompromised people prone to fungal infections? What kinds of fungal infections? What happens when a fungal infection gains access to the systemic circulation? Is that a dangerous infection or one which you should not worry about?

What is the Pma1p? What does it do in yeast? Why might it be a good target for the develpment of novel antifungals? Can you name one compound used by Dr. Billack's lab which inhibits Pma1p?