Antimicrobial Resistance- Part 3

From the chalkboard lecture:

1. Why is the pig (swine) a potential threat to the development of flu viruses capable of infecting humans?

2. As of today, how many cases of swine flu have been reported in Mexico? How many deaths?

3. As of today, how many cases of swine flu have been reported in the USA? How many deaths?

4. What has NYC done to try to prepare for a swine flu pandemic?

---FUNGI---

List at three three types of fungal pathogens that can causes disease in humans.

What types of infections can be caused by Candida albicans?

What is the mechanism of action of terbinafine? What is the mechanism of action of fluconazole? voriconazole? ketoconazole?

What is the mechanism of action of amphotericin B? Why is ergosterol important to the fungi? Do humans have ergosterol in their cell membranes?

What gene is upregulated in yeasts which are resistant to fluconazole? Why do we worry about fluconazole-resistance anyway?